Fumar en las psicosis afectivas: revisión sobre el consumo de nicotina en el trastorno bipolar y esquizoafectivo

Cristina López-Ortiz, Carlos Roncero, Laia Miquel, Miguel Casas

Resumen


Las psicosis afectivas incluyen aquellos trastornos con síntomas psicóticos y afectivos descritos en el DSM-IV-TR. En ellas, la prevalencia de la dependencia de nicotina es muy elevada. El objetivo es revisar la relación entre el consumo de nicotina y las psicosis afectivas a nivel epidemiológico, clínico, pronóstico, y de tratamiento. Se revisan los artículos publicados en la base PubMed que incluyen las palabras fumar, tabaco, nicotina y trastorno esquizoafectivo o bipolar. La comorbilidad del trastorno bipolar y el trastorno esquizoafectivo con el consumo de nicotina es de 66-82,5% y del 67% respectivamente. Tras esta revisión se puede concluir que el hábito tabáquico determina un peor pronóstico y mayor gravedad clínica del trastorno bipolar y esquizoafectivo. El consumo de otras sustancias, el diagnóstico, el consumo de cafeína y la gravedad clínica son factores de riesgo para el consumo de nicotina. El tratamiento más efectivo es el farmacológico en combinación con el psicológico. Los medicamentos de primera línea para la desintoxicación y deshabituación tabáquica son la terapia sustitutiva (parches transdérmicos, aerosoles, tabletas sublinguales, comprimidos para chupar o chicles de nicotina), la vareniclina y el bupropion. El tratamiento indicado para los síntomas psicóticos son los antipsicóticos atípicos por su mejor perfil de tolerabilidad y mejores resultados para el abandono del hábito tabáquico.

 


Palabras clave


patología dual; trastorno esquizoafectivo; trastorno bipolar; nicotina; fumar; tabaco

Texto completo:

PDF

Referencias


American Psychiatric Association. DSM-IV-TR. Manual diagnóstico y estadístico de los trastornos mentales. Texto revisado. Barcelona: Masson, 2003.

Angst J, Gamma A, Benazzi F, Ajdacic V, Eich D, Rössler W. Toward a re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania. J Affect Disord 2003; 73: 133-46.

Pedrejón C, Espiño I, Araúxo A. Diagnóstico diferencial y comorbilidad

en los trastornos esquizoafectivos. En: Benabarre A. Trastornos esquizoafectivos. Barcelona: ESPAXS; 2007. p. 73-5.

Markou A, Kosten TR, Koob, GF. Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology 1998; 19: 135-74.

Nolen WA, Luckenbaugh DA, Altshuler LL, Suppes T, McElroy SL, Frye

MA, et al. Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network. Am J Psychiatry 2004; 161: 1447-54.

Casas M, Franco D, Goikolea JM, Jiménez-Arriero MA, Martínez-Raga J, Roncero C, et al. Trastorno bipolar asociado al uso de sustancias adictivas (patología dual). Revisión sistemática de la evidencia científica y consenso entre profesionales expertos. Actas Esp Psiquiatr 2008; 36: 350-61.

Lasser K, Boyd JW, Woolhandler S, Himmelstein DU, McCormick D, Bor DH. Smoking and mental illness: a population-based prevalence study. JAMA 2000; 284: 2606–10.

Hughes JR, Hatsukami DK, Mitchell JE, Dahlgren LA. Prevalence of smoking among psychiatric outpatients. Am J Psychiatry 1986; 143: 993-7.

De Leon J, Abraham G, Nair C, Verghese C, McGrory A, McCann E.

Nicotine addiction in chronic schizophrenia. Biol Psychiatry 1995a; 37: 640.

De Leon J, Dadvand M, Canuso C, White AO, Stanilla J, Simpson GM.

Schizophrenia and smoking: an epidemiological survey in a state hospital. Am J Psychiatry 1995b; 152: 453-5.

Breslau N, Johnson EO, Hiripi E, Kessler R. Nicotine dependence in the United States: prevalence, trends, and smoking persistence. Arch Gen Psychiatry 2001; 58: 810-6.

Vanable PA, Carey MP, Carey KB, Maisto SA. Smoking among psychiatric outpatients: relationship to substance use, diagnosis, and illness severity. Psychol Addict Behav 2003; 17: 259-65.

Martínez Ortega JM, Gurpegui M, Díaz FJ, De León J. Tabaco y esquizofrenia. Adicciones 2004; 16 Supl 2: 177-90.

Breslau N, Kilbey MM, Andreski P. Vulnerability to psychopathology in

nicotine-dependent smokers: an epidemiologic study of young adults. Am J Psychiatry 1993; 150: 941–6.

Hall RG, Duhamel M, McClanahan R, Miles G, Nason C, Rosen S, et al. Level of functioning, severity of illness, and smoking status among chronic psychiatric patients. J Nerv Ment Dis 1995; 183: 468-71.

Bruce ML, Leaf PJ, Rozal GP, Florio L, Hoff RA. Psychiatric status and 9-year mortality data in the New Haven Epidemiologic Catchment Area Study. Am J Psychiatry 1994; 151: 716-21.

Glassman AH, Covey LS, Dalack GW, Stetner F, Rivelli SK, Fleiss J, et al. Smoking cessation, clonidine, and vulnerability to nicotine among dependent smokers. Clin Pharmacol Ther 1993; 54: 670–9.

Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, et al. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study.JAMA 1990; 264: 2511-8.

Kessler RC, Nelson CB, McGonagle KA, Edlund MJ, Frank RG, Leaf PJ. The epidemiology of co-occurring addictive and mental disorders: implications for prevention and service utilization. Am J Orthopsychiatry 1996; 66: 17-31.

DelBello MP, Hanseman D, Adler CM, Fleck DE, Strakowski SM. Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode. Am J Psychiatry 2007; 164: 582–90.

Diaz FJ, James D, Botts S, Maw L, Susce MT, de Leon J. Tobacco smoking behaviors in bipolar disorder: a comparison of the general population, schizophrenia, and major depression. Bipolar Disord 2009; 11: 154-65.

Waxmonsky JA, Thomas MR, Miklowitz DJ, Allen MH, Wisniewski SR, Zhang H, et al. Prevalence and correlates of tobacco use in bipolar disorder: data from the first 2000 participants in the Systematic Treatment Enhancement Program. Gen Hosp Psychiatry 2005; 27: 321–8.

Gonzalez-Pinto A, Gutierrez M, Ezcurra J, Aizpuru F, Mosquera F, Lopez P, et al. Tobacco smoking and bipolar disorder. J Clin Psychiatry 1998; 59: 225–8.

Wilens TE, Biederman J, Milberger S, Hahesy AL, Goldman S, Wozniak J, et al. Is bipolar disorder a risk for cigarette smoking in ADHD youth? Am J Addict 2000; 9: 187–95.

Goldstein BI, Birmaher B, Axelson DA, Goldstein TR, Esposito-Smythers

C, Strober MA, et al. Significance of cigarette smoking among youths with bipolar disorder. Am J Addict 2008; 17: 364-71.

Gurrea A, Pinet MC. Tabaco y patología afectiva. Adicciones 2004; 16

Supl 2: 155-76.

Scully PJ, Owens JM, Kinsella A, Waddington JL. Schizophrenia, schizoaffective and bipolar disorder within an epidemiologically complete, homogeneous population in rural Ireland: small area variation in rate. Schizophr Res 2004; 67: 143-55.

Azorin JM, Kaladjian A, Fakra E. Current issues on schizoaffective disorder. Encephale 2005; 31: 359-65.

Schwartz JE, Fennig S, Tanenberg-Karant M, Carlson G, Craig T,Galambos N, et al. Congruence of diagnoses 2 years after a first-admission diagnosis of psychosis. Arch Gen Psychiatry 2000; 57: 593–600.

Farrell M, Howes S, Bebbington P, Brugha T, Jenkins R, Lewis G, et al. Nicotine, alcohol and drug dependence and psychiatric comorbidity. Results of a national household survey. Br J Psychiatry 2001; 179: 432-7.

Kessler DA, Barnett PS, Witt A, Zeller MR, Mande JR, Schultz WB. The

legal and scientific basis for FDA’s assertion of jurisdiction over cigarettes and smokeless tobacco. JAMA 1997; 277: 405-9.

Breslau N, Kilbey M, Andreski P. Nicotine dependence, major depression, and anxiety in young adults. Arch Gen Psychiatry 1991; 48: 1069-74.

Black DW, Zimmerman M, Coryell WH. Cigarette smoking and psychiatric disorder in a community sample. Ann Clin Psychiatry 1999; 11: 129-36.

Dervaux A, Baylé FJ, Laqueille X, Bourdel MC, Le Borgne MH, Olié JP, et al. Nicotine use in schizophrenia and disinhibition. Psychiatry Res 2004; 128: 229-34.

Levin ED, Wilson W, Rose J, McEvoy J. Nicotine–haloperidol interactions and cognitive performances in schizophrenics. Neuropsychopharmacology 1996; 15: 429–36.

Dalack GW, Healy DJ, Meador-Woodruff JH. Nicotina dependence in

schizophrenia: clinical phenomena and laboratory findings. Am J Psychiatry 1998; 155: 1490– 501.

Breese CR, Lee MJ, Adams CE, Sullivan B, Logel J, Gillen KM, et al.

Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia. Neuropharmacol 2000; 23: 351–64.

Freedman R. Exacerbation of schizophrenia by varenicline. Am J Psychiatry 2007; 164: 1269.

Adler LE, Hoffer LD, Wiser A, Freedman R. Normalization of auditory

physiology by cigarette smoking in schizophrenic patients. Am J

Psychiatry 1993; 150: 1856– 61.

Adler LE, Olincy A, Waldo M, Harris J, Griffith J, Stevens K, et al.

Schizophrenia, sensory gating, and nicotinic receptors.

Schizophr Bull 1998; 24: 189–202.

Baker A, Richmond R, Haile M, Lewin TJ, Carr VJ, Taylor RL, et al.

Characteristics of smokers with a psychotic disorder and implications for smoking interventions. Psychiatry Res 2007; 150: 141-52.

Altamura AC, Bassetti R, Bignotti S, Pioli R, Mundo E. Clinical variables

related to suicide attempts in schizophrenic patients: a retrospective study. Schizophr Res 2003; 60: 47-55.

Corvin A, O’Mahony E, O’Regan M, Comerford C, O’Connell R, Craddock N, et al. Cigarette smoking and psychotic symptoms in bipolar affective disorder. Br J Psychiatry 2001; 179: 35–38.

Graff FS, Griffin ML, Weiss RD. Predictors of dropout from group

therapy among patients with bipolar and substance use disorders. Drug Alcohol Depend 2008; 94: 272-5.

Ostacher MJ, Lebeau RT, Perlis RH, Nierenberg AA, Lund HG, Moshier

SJ, et al. Cigarette smoking is associated with suicidality in bipolar disorder. Bipolar Disord 2009; 11: 766-71.

Osby U, Brandt L, Correia N, Ekbom A, Sparen P. Excess mortality in

bipolar and unipolar disorder in Sweden. Arch Gen Psychiatry 2001; 58: 844–50.

Tsuang MT, Woolson RF, Fleming JA. Causes of death in schizophrenia

and manic-depression. Br J Psychiatry 1980; 136: 239–42.

Grant BF, Hasin DS, Chou SP, Stinson FS, Dawson DA. Nicotine dependence and psychiatric disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions. Arch Gen Psychiatry 2004; 61: 1107–15.

Kilbourne A, Salloum I, Dausey D, Cornelius J, Conigliaro J, Xu X, et

al. Quality of care for substance use disorders in patients with serious mental illness. J Subst Abuse Treat 2006; 30: 73-7.

Dwyer JH, Rieger-Ndakorerwa GE, Semmer NK, Fuchs R, Lippert P. Low-level cigarette smoking and longitudinal change in serum cholesterol among adolescents. The Berlin-Bremen Study. JAMA 1988; 259: 2857– 62.

Tidey JW, Rohsenow DJ. Smoking expectancies and intention to quit in smokers with schizophrenia, schizoaffective disorder and non-psychiatric controls. Schizophr Res 2009; 115: 310-6.

Williams JM, Gandhi KK, Steinberg ML, Foulds J, Ziedonis DM, Benowitz NL. Higher nicotine and carbon monoxide levels in menthol cigarette smokers with and without schizophrenia. Nicotine Tob Res 2007; 9: 873-81.

Williams JM, Foulds J. Successful tobacco dependence treatment in

schizophrenia. Am J Psychiatry 2007; 164: 222-7. Breslau N, Peterson EL. Smoking cessation in young adults: age at initiation of cigarette smoking and other suspected influences. Am J Public Health 1996; 86: 214-20.

Gershon Grand RB, Hwang S, Han J, George T, Brody AL. Short-term

naturalistic treatment outcomes in cigarette smokers with substance abuse and/or mental illness. Clin Psychiatry 2007; 68:892-8.

Smelson DA, Losonczy MF, Davis CW, Kaune M, Williams J, Ziedonis D.

Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence. Can J Psychiatry 2002; 47: 671-5.

De Leon J. Smoking and vulnerability for schizophrenia. Schizophr Bull

; 22: 405–9.

Tidey JW, Rohsenow DJ, Kaplan GB, Swift RM. Cigarette smoking topography in smokers with schizophrenia and matched nonpsychiatric

controls. Drug Alcohol Depend 2005; 80: 259-65.

Cerullo MA, Strakowski SM. The prevalence and significance of substance use disorders in bipolar type I and II disorder. Subst Abuse Treat Prev Policy 2007; 2: 29.

Brown ES, Jeffress J, Liggin JD, Garza M, Beard L. Switching outpatients with bipolar or schizoaffective disorders and substance abuse from their current antipsychotic to aripiprazole. J Clin Psychiatry 2005; 66: 756-60.

Dudas MM, George TP. Non-nicotine pharmacotherapies for nicotine

dependence. Essent Psychopharmacol 2005; 6: 158-72.

Herrero García De Osma FJ, Moreno Arnedillo JJ. Tratamientos combinados del tabaquismo: psicológicos y farmacológicos. Adicciones 2004; 16 Supl 2: 287-320.

Pereiro C, Becoña E, Córdoba R, Martínez J, Pinet C. Tabaquismo. Guías

Clínicas Socidrogalcohol basadas en la evidencia científica. Valencia: Socidrogalcohol; 2008.

Sociedad Española de Neumología y Cirugía Torácica. Manuales SEPAR, Tabaquismo. Volumen 1. Madrid: SEPAR, 1995.

Fiore MC, Bailay WC, Cohen SJ. Treating tobacco use and dependence.

Clinical Practice Guideline. Rockville, MD: US Department of Health and Human Services. Public Health Service, 2000.

Silagy C, Mant D, Fowler G, Lancaster T. Nicotine replacement therapy

for smoking cessation. Database of abstracts of reviews of effectiveness. En: Cochrane Library, Issue 2. Oxford: update software, 1998.

Pinet C. Tratamiento del tabaquismo. En: Bobes J, Casas M, Gutiérrez M, editores. Manual de evaluación y tratamiento de drogodependencias. Barcelona: Ars Medica; 2003.

Sáiz Martínez PA, García-Portilla González MP, Martínez Larrondo S, Bascarán Fernández MT, Paredes Ojanguren B, Bobes García J. Tratamiento farmacológico. Psicofármacos. Adicciones 2004; 16 Supl 2: 275-85.

Haro G, Cervera G, Martinez-Raga J, Pérez-Gálvez B, Fernandez-Garcés M, Sanjuan J. Pharmacological treatment of substance dependence from a neuroscientific perspective (II): alcohol, benzodiazepines and nicotine. Actas Esp Psiquiatr 2003; 31:284-98.

Murray RP, Voelker HT, Rakos RF, Nides MA, McCutcheon VJ, Bjornson

W. Intervention for relapse to smoking: the Lung Health Study restart programs. Addict Behav 1997; 22: 281-6.

Hajek P, West R, Foulds J, Nilsson F, Burrows S, Meadow A. Randomized

comparative trial of nicotine polacrilex, a transdermal patch, nasal spray and an inhaler. Arch Intern Med 1999; 159: 2033–8.

George TP, Ziedonis DM, Feingold A, Pepper WT, Satterburg CA, Winkel

J, et al. Nicotine transdermal patch and atypical antipsychotic medications for smoking cessation in schizophrenia. Am J Psychiatry 2000; 157: 1835-42.

Gerlach J, Larsen EB. Subjective experience and mental side-effects

of antipsychotic treatment. Acta Psychiatr Scand 1999; 395: 113–7.

Addington J, el Guebaly N, Campbell W, Hodgins DC, Addington D.

Smoking cessation treatment for patients with schizophrenia. Am J Psychiatry 1998; 155: 974–6.

Dalack GW, Becks L, Hill E, Pomerleau OF, Meador-Woodruff JH.

Nicotine withdrawal and psychiatric symptoms in cigarette smokers with schizophrenia. Neuropsychopharmacology 1999; 21: 195–202.

Williams JM, Gandhi KK, Karavidas MK, Steinberg ML, Lu SE, Foulds J. Open-label study of craving in smokers with schizophrenia using nicotine nasal spray compared to nicotine patch. J Dual Diagn 2008; 4: 355-76.

Benowitz NL, Zevin S, Jacob P 3rd. Sources of variability in nicotine

and cotinine levels with use of nicotine nasal spray, transdermal nicotine, and cigarette smoking. Br J Clin Pharmacol 1997; 43: 259-67.

Sutherland G, Russell MAH, Stapleton J, Feyerabend C, Ferno O. Nasal nicotine spray: a rapid nicotine delivery system. Psychopharmacology 1992; 108: 512–8.

Perkins KA, Jacobs L, Clark L, Conklin CA, Sayette M, Wilson A. Instructions about nicotine dose influence acute responses to nasal spray. Nicotine Tob Res 2004; 6: 1051-60.

Tilashalski K, Rodu B, Cole P. A pilot study of smokeless tobacco in

smoking cessation. Am J Med 1998; 104: 456–8.

Bunch R, Thomas M, Bunch N. Smokeless tobacco for a nicotinedependent

schizoaffective patient. Am J Psychiatry 2005; 162: 1543-4.

Gonzales D, Bennard S, Nides M, Oncken C, Azoulay S, Billing C, et al. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo smoking cessation. JAMA 2006; 296: 47–55.

Kohen I, Kremen N. Varenicline-induced manic episode in a patient with bipolar disorder. Am J Psychiatry 2007; 164: 1269–70.

Morstad AE, Kutscher EC. Hypomania and agitation associated with varenicline use in bipolar II disorder. Ann Pharmacother 2008; 42: 288–9.

Smith RC, Lindenmayer JP, Davis JM, Cornwell J, Noth K, Gupta S, et

al. Cognitive and antismoking effects of varenicline in patients with schizophrenia or schizoaffective disorder. Schizophr Res 2009; 110: 149-55.

DiPaula BA, Thomas MD. Worsening psychosis induced by varenicline

in a hospitalized psychiatric patient. Pharmacotherapy 2009; 29: 852-7.

Alhatem F, Black JE. Varenicline-induced mania in a bipolar patient.

Clin Neuropharmacol 2009; 32: 117-8.

Mihakak K, Carroll F, Luetje C. Varenicline is a parietal agonist at {alpha] 4{beta}2 and a full agonist at {alpha}7 neuronal nicotinic receptors. Mol Pharmacol 2006; 70: 801–5.

Clayton AH. Extended-release bupropion: an antidepressant with a broad spectrum of therapeutic activity? Expert Opin Pharmacother. 2007; 8: 457-66.

Hays JT, Hurt RD, Rigotti NA, Niaura R, Gonzales D, Durcan MJ, et al. Sustained release bupropion for pharmacologic relapse prevention after smoking cessation. a randomized, controlled trial. Ann Intern Med 2001; 135: 423-33.

Hurt RD, Sachs DP, Glover ED, Offord KP, Johnston JA, Dale LC, et al.

A comparison of sustained-release bupropion and placebo for smoking cessation. N Engl J Med 1997; 337: 1195-202.

Evins AE, Mays VK, Rigotti NA, Tisdale T, Daigle A, Goff DC. Reduction

in tobacco use in schizophrenia with bupropion SR and cognitive behavioral therapy. Abstract of the 6th Annual Meeting of the Society for Research on Nicotine and Tobacco. Middleton, Wis, 2000.

George TP, Vessicchio JC, Termine A, Bregartner TA, Feingold A, Rounsaville BJ, et al. A placebo controlled trial of bupropion for smoking cessation in schizophrenia. Biol Psychiatry 2002; 52:53-61.

Javelot H, Baratta A, Weiner L, Javelot T, Nonnenmacher C, Westphal

JF, et al. Two acute psychotic episodes after administration of bupropion: a case of involuntary rechallenge. Pharm World Sci 2009; 31: 238-40.

Yatham LN, Kennedy SH, Schaffer A, Parikh SV, Beaulieu S, O’Donovan C, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009.

Bipolar Disord 2009; 11: 225-55.

Lee HJ, Rao JS, Chang L, Rapoport SI, Kim HW. Chronic imipramine but

not bupropion increases arachidonic acid signaling in rat brain: is this related to ‘switching’ in bipolar disorder? Mol Psychiatry. 2008; doi:10.1038/mp.2008.117.

Leverich GS, Altshuler LL, Frye MA, Suppes T, McElroy SL, Keck PE Jr,

et al. Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers. Am J Psychiatry 2006; 163: 232-9.

Wilens TE, Prince JB, Spencer T, Van Patten SL, Doyle R, Girard K, et al. An open trial of bupropion for the treatment of adults with attention-deficit/hyperactivity disorder and bipolar disorder. Biol Psychiatry 2003; 54: 9-16.

Joffe RT, MacQueen GM, Marriott M, Robb J, Begin H, Young LT. Induction of mania and cycle acceleration in bipolar disorder: effect of different classes of antidepressant. Acta Psychiatr Scand 2002; 105: 427-30.

Truman CJ, Goldberg JF, Ghaemi SN, Baldassano CF, Wisniewski SR,

Dennehy EB, et al. Self-reported history of manic/hypomanic switch associated with antidepressant use: data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). J Clin Psychiatry 2007; 68: 1472-9.

Dervaux A, Laqueille X. Antidepressant Treatment and Smoking

Cessation in Bipolar Disorder. JAMA 2009; 301: 2093.

Hayford KE, Patten CA, Rummans TA, Schroeder DR, Offord KP, Croghan IT, et al. Efficacy of bupropion for smoking cessation in smokers with a former history of major depression or alcoholism. Br J Psychiatry 1999; 174: 173-8.

Becoña E. Tratamiento psicológico del tabaquismo. Adicciones 2004;

Supl 2: 237-63.

Roncero C, López-Ortiz C, Barral C, Sáez-Francàs N, Rovira M, Casas M.

Tratamiento concomitante de litio y metadona en un paciente bipolar: a propósito de un caso. Adicciones 2009; 21: 131-42.

Chengappa K, Gershon L, Kupfer D. Lifetime prevalence of substance

or alcohol abuse and dependence among subjects with bipolar I and II disorders in a voluntary registry. Bipolar Disord 2000; 2:191-5.

Szerman N, Basurte I, Vega P, Arias F, Poyo F, Mesias B, et al. Estudio

epidemiológico para determinar la prevalencia, diagnóstico y actitud terapéutica de la patología dual en la Comunidad de Madrid. Disponible en http://www.patologiadual.es/docs.htm [última modificación en noviembre de 2008; consultado el 19 de enero de 2010].

Dueñas Herrero RM, Aleu Bover M, González Tejón I, San Molina L, Salavert Jiménez J, Arranz B, et al. El papel del consejo antitabaco en el proceso de deshabituación en enfermos mentales. Actas Esp Psiquiatr 2004; 32: 287-92.

Torrecillas García M, Barrueco M, Maderuelo JA, Jiménez Ruiz C, Plaza

Martín M, Hernández Mezquita M. El abordaje del tabaquismo en Atención primaria y especializada, una oportunidad real y una necesidad de salud pública. Atención Primaria 2002; 30:197-206.

Lorenzo P, Ladero JM. Dependencia tabáquica. Tabaco y nicotina.

En: Lorenzo P, Ladero JM, Leza JC, Lizasoian I, eds. Drogodependencias. Farmacología. Patología. Psicología. Legislación. Madrid: Ed. Médica Panamericana, 2003.

De Leon J. Atypical antipsychotic dosing: the effect of smoking and

caffeine. Psychiatr Serv 2004; 55: 491-3.

Gurpegui M, Aguilar MC, Martínez-Ortega JM, Diaz FJ, de Leon J. Caffeine intake in outpatients with schizophrenia. Schizophr Bull 2004; 30: 935-45.

McEvoy J, Freudenreich O, Levin E, Rose J. Haloperidol increases smoking in patients with schizophrenia. Psychopharmacology (Berl) 1995a; 119: 124–6.

Green AI, Zimmet SV, Strous RD, Schildkraut JJ. Clozapine for comorbid substance use disorder and schizophrenia: do patients with schizophrenia have a reward-deficiency syndrome that can be ameliorated by clozapine? Harv Rev Psychiatry 1999; 6: 287-96.

Gerra G, Di Petta G, D’Amore A, Iannotta P, Bardicchia F, Falorni F, et al. Combination of olanzapine with opioid-agonists in the treatment of eroin-addicted patients affected by comorbid schizophrenia spectrum disorders. Clin Neuropharmacol 2007; 30: 127-35.

Westerink BH, Kawahara Y, De Boer P, Geels C, De Vries JB, Wikström

HV, et al. Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum. Eur J Pharmacol 2001; 412: 127-38.

Sattar SP, Bhatia SC, Petty F. Potential benefits of quetiapine in the

treatment of substance dependence disorders. J Psychiatry Neurosci 2004; 29: 452-7.

Zimmet SV, Strous RD, Burgess ES, Kohnstamm S, Green AI. Effects

of clozapine on substance use in patients with schizophrenia and schizoaffective disorder: a retrospective survey. J Clin Psychopharmacol 2000; 20: 94-8.

Littrell KH, Petty RG, Hilligoss NM, Peabody CD, Johnson CG. Olanzapine treatment for patients with schizophrenia and substance abuse. J Subst Abuse Treat 2001; 21: 217-21.

Keck PE Jr, Marcus R, Tourkodimitris S, Ali M, Liebeskind A, Saha A, et

al. Aripiprazole Study Group. A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania. Am J Psychiatry 2003; 160: 1651-8.

Sattar SP, Grant K, Bhatia S, Petty F. Potential use of olanzapine in treatment of substance dependence disorders. J Clin Psychopharmacol 2003; 23: 413-5.

Potvin S, Stip E, Roy J. The effect of quetiapine on cannabis use in 8 psychosis patients with drug dependency. Can J Psychiatry 2004; 49: 711.

Brunette MF, Drake RE, Xie H, McHugo GJ, Green AI. Clozapine use

and relapses of substance use disorder among patients with co-occurring schizophrenia and substance use disorders.

Schizophr Bull 2006; 32: 637-43.

George TP, Sernyak MJ, Ziedonis DM, Woods SW. Effects of clozapine

on smoking in chronic schizophrenic outpatients. J Clin Psychiatry 1995; 56: 344-6.

McEvoy JP, Freudenreich O, Wilson WH. Smoking and therapeutic response to clozapine in patients with schizophrenia. Biol Psychiatry 1999; 46: 125–9.

Drake R, Xie H, McHugo GJ, Green AI. The effects of clozapine on alcohol and drug use disorders among patients with schizophrenia. Schizophr Bull 2000; 26: 441-9.

Lafayette JM, Frankle WG, Pollock A, Dyer K, Goff DC. Clinical characteristics, cognitive functioning, and criminal histories of outpatients with schizophrenia. Psychiatr Serv 2003; 54: 1635-40.

Fiore MC, Jaén CR, Baker TB, et al. Treating Tobacco Use and Dependence: 2008 Update. Clinical Practice Guideline. Rockville, MD: U.S. Department of Health and Human Services. Public Health Service. May 2008. p. 146.




DOI: https://doi.org/10.20882/adicciones.168

Enlaces refback

  • No hay ningún enlace refback.