“Diazepam loading”: ¿Can a strategy for preventing alcohol withdrawal be used to treat benzodiazepine use disorder?

Authors

  • Clara Oliveras Hospital Clínic i Universitari de Barcelona http://orcid.org/0000-0003-4291-8007
  • Adriana Fortea Hospital Clínic i Universitari de Barcelona
  • Laura Espinosa Hospital Clínic i Universitari de Barcelona
  • Pablo Barrio Hospital Clínic i Universitari de Barcelona
  • Anna Lligoña Hospital Clínic i Universitari de Barcelona
  • Mercè Balcells-Olivero Hospital Clínic i Universitari de Barcelona

DOI:

https://doi.org/10.20882/adicciones.1058

Keywords:

Benzodiacepinas, Abstinencia, Desintoxicación, Diazepam

Abstract

Benzodiazepines (BZDs) are central nervous system (CNS) depressants which are widely used to treat insomnia and anxiety, despite having long-term adverse side effects. (Fortea González, Oriolo, Balcells Oliveró, Sánchez Del Valle & Castellvi, 2017). As with alcohol, continued use can lead to tolerance and dependence phenomena. Discontinuation in such cases can produce abstinence symptoms such as tremors, anxiety, seizures and, occasionally, death (Brett y Murnion, 2015).

Author Biographies

Clara Oliveras, Hospital Clínic i Universitari de Barcelona

Addictions Unit. Psychiatry Department. Clinical Neuroscience Institute. Hospital Clínic i Universitari de Barcelona. Spain

Adriana Fortea, Hospital Clínic i Universitari de Barcelona

Addictions Unit. Psychiatry Department. Clinical Neuroscience Institute. Hospital Clínic i Universitari de Barcelona. Spain

Laura Espinosa, Hospital Clínic i Universitari de Barcelona

Addictions Unit. Psychiatry Department. Clinical Neuroscience Institute. Hospital Clínic i Universitari de Barcelona. Spain

Pablo Barrio, Hospital Clínic i Universitari de Barcelona

Addictions Unit. Psychiatry Department. Clinical Neuroscience Institute. Hospital Clínic i Universitari de Barcelona. Spain

Anna Lligoña, Hospital Clínic i Universitari de Barcelona

Addictions Unit. Psychiatry Department. Clinical Neuroscience Institute. Hospital Clínic i Universitari de Barcelona. Spain

References

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Brett, J. y Murnion, B. (2015). Management of benzodiazepine misuse and dependence. Australian Prescriber, 38, 152–155. doi:10.18773/austprescr.2015.055.

Fortea González, A., Oriolo, G., Balcells Oliveró, M., Sanchez del Valle, R. y Castellvi, M. (2017). Deterioro cognitivo secundario a trastorno por uso de benzodiacepinas y su reversibilidad: a propósito de un caso. Adicciones, 29, 61-63. doi:10.20882/adicciones.767.

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Lligoña, A. (2007). Tratamiento de la abstinencia alcohólica con benzodiacepinas. Una revisión. Aula Médica Psiquiatría, 2, 65–77.

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Sellers, E. M. (1988). Alcohol, barbiturate and benzodiazepine withdrawal syndromes: Clinical management. Canadian Medical Association Journal, 139, 113–120.

Wasilewski, D., Matsumoto, H., Kur, E., Dziklińska, A., Woźny, E., Stencka, K., … Szelenberger, W. (1996). Assessment of diazepam loading dose therapy of delirium tremens. Alcohol and Alcoholism, 31, 273–278.

Published

2018-04-15

Issue

Section

Letters to the Editors