Alcohol and adolescent brain
DOI:
https://doi.org/10.20882/adicciones.246Keywords:
alcohol, binge drinking, adolescence, brain, cognitive functionAbstract
Binge Drinking (BD) pattern is firmly established among adolescents and young people. This pattern has raised a strong concern within the neuroscience community due to its possible impact on specific brain regions still maturing. Research with animal models demonstrates that BD may have serious structural and functional effects during these ages. Some regions like the prefrontal cortex or the hippocampus and the cognitive processes in which these structures play a role seem to be specific targets of alcohol. Results provided by the scarce studies carried out in humans support the evidence from previous animal experiments. However, we are far from being able to answer if this pattern of consumption has a special effect in the adolescent brain and what the short and long-term consequences are. Common limitations in human studies include the insufficient control of powerful confounding factors, the use of designs that does not allow differentiation between markers and effects, the use of reduced samples and the lack of replication studies. Although the innocuousness hypothesis is no longer sustained and experimental evidence has accumulated showing the risk associated with BD, results have been somewhat overinterpretated. The valuable contributions of cross-sectional designs should be complemented by the contributions of prospective longitudinal studies with appropriated sample sizes and a higher control of critical variables in order to identify short and long-term structural and neurocognitive consequences.References
Observatorio Español sobre Drogas. Encuesta Estatal sobre uso de
drogas en estudiantes de enseñanzas secundarias (ESTUDES) 2006-2007. Madrid. Ministerio de Sanidad y Consumo. Delegación del Gobierno para el Plan Nacional sobre Drogas, 2007.
National Institute on Alcohol Abuse and Alcoholism. NIAAA Council
Approves Definitión of Binge Drinking. NIAAA Newsletter 2004; 3: 3.
Pfefferbaum A, Rosenbloom M, Deshmukh A, Sullivan E. Sex differences in the effects of alcohol on brain structure. Am J Psychiatry 2001; 158: 188-97.
Wuethrich B. Neurobiology. Does alcohol damage female brains more? Science (2001; 291: 2077-9.
Caldwell LC, Schweinsburg AD, Nagel BJ, Barlett VC, Brown SA, Tapert SF. Gender and adolescent alcohol use disorders on BOLD (blood oxygen level dependent) response to spatial working memory. Alcohol Alcohol 2000; 40: 194-200.
Townshend JM, Duka T. Binge drinking, cognitive performance and
mood in a population of young social drinkers. Alcohol Clin Exp Res 2005; 29: 317-25.
Observatorio Español sobre Drogas. Informe de la Encuesta Domiciliaria sobre Alcohol y Drogas en España (EDADES) 2007-2008. Recuperado el 6 de febrero de 2009, de http://www.pnsd.msc.es/Categoria2/observa/pdf/InformeEdades2007-2008.pdf.
Grant BF, Dawson DA. Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. J Subst Abuse 1997; 9: 103-10.
Caamaño-Isorna F, Corral M, Parada M, Cadaveira F. Factors associated with risky alcohol use and heavy episodic drinking among Spanish university students. J Stud Alcohol Drugs 2008; 69: 308-12.
Andersson BH, B.; Beck, F.; Choquet, M.; Kokkevi, A.; Fotiou, A. Alcohol and Drug Use Among European 17–18 Year Old Students. Data from the ESPAD Project. Swedish Council for Information on Alcohol and Other Drugs (CAN), The Pompidou Group at the Council of Europe ed. Stockholm: Modintryckoffset AB 2007.
Cadaveira F, Roso M, Grau C, Sanchez-Turet M. Effects of age on
event-related potentials in chronic alcoholics: a multimodal study. Neuropsychobiology. 1992; 25: 166-71.
Hunt WA. Are binge drinkers more at risk of developing brain damage? Alcohol 1993; 10: 559-61.
Crews FT, Braun CJ, Hoplight B, Switzer RC, Knapp DJ. Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats. Alcohol Clin Exp Res 2000; 24: 1712-23.
Swartzwelder HS, Wilson WA, Tayyeb MI. Differential sensitivity
of NMDA receptor-mediated synaptic potentials to ethanol in immature versus mature hippocampus. Alcohol Clin Exp Res 1995; 19: 320-3.
Swartzwelder HS, Wilson WA, Tayyeb MI. Age-dependent inhibition
of long-term potentiation by ethanol in immature versus mature hippocampus. Alcohol Clin Exp Res 1995; 19: 1480-5.
Crews FT, Mdzinarishvili A, Kim D, He J, Nixon K. Neurogenesis in
adolescent brain is potently inhibited by ethanol. Neuroscience 2006; 137: 437-45.
Pascual M, Blanco AM, Cauli O, Minarro J, Guerri C. Intermittent
ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats. Eur J Neurosci 2007; 25: 541-50.
Collins MA, Corso TD, Neafsey EJ. Neuronal degeneration in rat
cerebrocortical and olfactory regions during subchronic “binge” intoxication with ethanol: possible explanation for olfactory deficits in alcoholics. Alcohol Clin Exp Res 1996; 20: 284-92.
Crews F, ed. Neurotoxicity of alcohol: excitotoxicity, oxidative
stress, neurotrophic factors, apoptosis, and cell adhesion molecules. Bethesda, MD.: NIAAA 2000.
Markwiese BJ, Acheson SK, Levin ED, Wilson WA, Swartzwelder
HS. Differential effects of ethanol on memory in adolescent and adult rats. Alcohol Clin Exp Res 1998; 22: 416-21.
White AM, Ghia AJ, Levin ED, Swartzwelder HS. Binge pattern
ethanol exposure in adolescent and adult rats: differential impact on subsequent responsiveness to ethanol. Alcohol Clin Exp Res 2000; 24: 1251-6.
Silvers JM, Tokunaga S, Mittleman G, Matthews DB. Chronic intermittent injections of high-dose ethanol during adolescence produce metabolic, hypnotic, and cognitive tolerance in rats. Alcohol Clin Exp Res 2003; 27: 1606-12.
White AM, Swartzwelder HS. Age-related effects of alcohol on memory and memory-related brain function in adolescents and adults. Recent Dev Alcohol 2005; 17: 161-76.
Crews F, He J, Hodge C. Adolescent cortical development: a critical
period of vulnerability for addiction. Pharmacol Biochem Behav 2007; 86: 189-99.
Luna B, Sweeney JA. The emergence of collaborative brain function:
FMRI studies of the development of response inhibition. Ann NY Acad Sci 2004; 1021: 296-309.
Stuss DT, Levine B. Adult clinical neuropsychology: lessons from
studies of the frontal lobes. Annu Rev Psychol 2002; 53: 401-33.
Medina KL, McQueeny T, Nagel BJ, Hanson KL, Schweinsburg AD,
Tapert SF. Prefrontal cortex volumes in adolescents with alcohol use disorders: unique gender effects. Alcohol Clin Exp Res 2008; 32: 386-94.
Pyapali GK, Turner DA, Wilson WA, Swartzwelder HS. Age and dosedependent effects of ethanol on the induction of hippocampal long-term potentiation. Alcohol 1999; 19: 107-11.
De Bellis MD, Clark DB, Beers SR, Soloff PH, Boring AM, Hall J, et al.
Hippocampal volume in adolescent-onset alcohol use disorders. Am J Psychiatry 2000; 157: 737-44.
Medina KL, Schweinsburg AD, Cohen-Zion M, Nagel BJ, Tapert SF. Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal volume and asymmetry. Neurotoxicol Teratol 2007; 29: 141-52.
Nagel BJ, Schweinsburg AD, Phan V, Tapert SF. Reduced hippocampal volume among adolescents with alcohol use disorders without psychiatric comorbidity. Psychiatry Res 2005; 139: 181-90.
Brown SA, Tapert SF. Adolescence and the trajectory of alcohol
use: basic to clinical studies. Ann N Y Acad Sci 2004; 1021: 234-44.
Tapert SF, Caldwell L, Burke C. Alcohol and the adolescent brain -
Human studies. Alcohol Res Health 2004; 28: 205-12.
Tapert SF, Schweinsburg AD. The human adolescent brain and alcohol use disorders. Recent Dev Alcohol 2005; 17: 177-97.
Brown SA, Tapert SF, Granholm E, Delis DC. Neurocognitive functioning of adolescents: effects of protracted alcohol use. Alcohol Clin Exp Res 2000; 24: 164-71.
Tapert SF, Granholm E, Leedy NG, Brown SA. Substance use and
withdrawal: neuropsychological functioning over 8 years in youth. J Int Neuropsychol Soc 2002; 8: 873-83.
Ehlers CL, Phillips E, Finnerman G, Gilder D, Lau P, Criado J. P3
components and adolescent binge drinking in Southwest California Indians. Neurotoxicol Teratol 2007; 29: 153-63.
García-Moreno LM. Actividad prefrontal y alcoholismo de fin de semana en jóvenes. Adicciones 2008; 20: 271-80.
Crego A, Rodríguez Holguín S, Parada M, Mota-Miranda N, Corral M, Caamaño-Isorna F, et al. Actividad electrofisiológica relacionada con memoria de trabajo visual en jóvenes consumidores intensivos de alcohol Comunicación presentada en las XXXV Jornadas Nacionales de Socidrogalcohol. A Coruña, 2008.
Parada M, Mota-Miranda N, Corral M, Crego A, Fernández-Eiré C, Rodríguez Holguín S, et al. Consumo intensivo de alcohol y memoria de trabajo en jóvenes universitarios: resultados preliminares. Póster presentado en las XXXV Jornadas Nacionales de Socidrogalcohol. A Coruña, 2008.
Chassin L, Pitts SC, Prost J. Binge drinking trajectories from
adolescence to emerging adulthood in a high-risk sample: predictors and substance abuse outcomes. J Consult Clin Psychol 2002; 70: 67-78.
Weissenborn R, Duka T. Acute alcohol effects on cognitive function in social drinkers: their relationship to drinking habits. Psychopharmacology 2003; 165: 306-12.
Corral MM, Holguin SR, Cadaveira F. Neuropsychological characteristics in children of alcoholics: familial density. J Stud Alcohol 1999; 60: 509-13.
Rodriguez Holguin S, Corral M, Cadaveira F. Event-related potentials elicited by infrequent non-target stimuli in young children of alcoholics: family history and gender differences. Alcohol Alcohol 1998; 33: 281-90.
Brown SA, McGue M, Maggs J, Schulenberg J, Hingson R, Swartzwelder S, et al. A developmental perspective on alcohol and youths 16 to 20 years of age. Pediatrics 2008; 121 Supl 4:S290-310.
Clark DB, Tapert SF. Introduction to alcohol and adolescent brain
development. Alcohol Clin Exp Res 2008; 32: 373-4.
Masten AS, Faden VB, Zucker RA, Spear LP. Underage drinking: a
developmental framework. Pediatrics 2008; 121 Supl 4: S235-51.
Berman SM, Noble EP. Reduced visuospatial performance in children with the D2 dopamine receptor A1 allele. Behav Genet 1995; 25: 45-58.
Corral M, Holguin SR, Cadaveira F. Neuropsychological characteristics of young children from high-density alcoholism families: a three-year follow-up. J Stud Alcohol 2003; 64:195-9.
Rodriguez Holguin S, Corral M, Cadaveira F. Event-related potentials elicited by a visual continuous performance task in children of alcoholics. Alcohol 1999; 19: 23-30.
Sartor CE, Lynskey MT, Heath AC, Jacob T, True W. The role of childhood risk factors in initiation of alcohol use and progression to alcohol dependence. Addiction 2007; 102: 216-25.
Aarons GA, Brown SA, Coe MT, Myers MG, Garland AF, Ezzet-Lofstram R, et al. Adolescent alcohol and drug abuse and health. J Adolesc Health 1999; 24: 412-21.
