Cognitive profile of long-term abstinent alcoholics in comparison with non-alcoholics
DOI:
https://doi.org/10.20882/adicciones.1079Keywords:
Abstinence, Alcohol related-cognitive deficits, Alcoholism, Empathy, Neuropsychology.Abstract
Scarce studies have focused on the cognitive profile of chronic alcoholic men after long-term abstinence. Thus, we examined neuropsychological differences between long-term abstinent alcoholics for an average of 3.2 years (n = 40, LTAA; age = 45.55 ± 8.99) and matched for socio-demographic variables with non-alcoholic controls (n = 39; age = 42.05 ± 11.33). To this aim, we employed a neuropsychological assessment battery covered relevant cognitive domains: IQ, memory, attention, executive functions and empathy. LTAA presented deficits in abstract reasoning, speed processing, sustained attention, working and long-term memory (verbal and visuospatial), cognitive flexibility, inhibition and planning. Although our results must be interpreted with caution because of the cross-sectional nature of our study, it may offer a broader knowledge and understanding of alcohol-related socio-cognitive deficits after long-term abstinence. These deficits might entail risk factors for relapse in alcohol consumption, as they may interfere with recording therapeutic advice and internalizing the verbal material presented in rehabilitation programs. In turn, these impair the global efficacy of alcohol-relapse prevention programs. Hence, this knowledge could be applicable in guiding the development of early coadjutant treatments.References
Abernathy, K., Chandler, L. J. y Woodward, J. J. (2010). Alcohol and the prefrontal cortex. International Review of Neurobiology, 91, 289-320. doi:10.1016/S0074-7742(10)91009-X.
Alhassoon, O. M., Sorg, S. F., Taylor, M. J., Stephan, R. A., Schweinsburg, B. C., Stricker, N. H.,... Grant, I. (2012). Callosal white matter microstructural recovery in abstinent alcoholics: a longitudinal diffusion tensor imaging study. Alcoholism: Clinical and Experimental Research, 36, 1922-1931. doi:10.1111/j.1530-0277.2012.01808.x.
Bagby, R. M., Parker, J. D. y Taylor, G. J. (1994). The twenty-item Toronto Alexithymia Scale—I. Item selection and cross-validation of the factor structure. Journal of Psychosomatic Research, 38, 23-32. doi:10.1016/0022-3999(94)90005-1.
Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y. y Plumb, I. (2001). The “Reading the Mind in the Eyes” Test revised version: A Study with Normal Adults, and Adults with Asperger Syndrome or High-functioning Autism. Journal of Child Psychology and Psychiatry, 42, 241-251. doi:10.1111/1469-7610.00715.
Bates, M.E., Voelbel, G.T., Buckman, J.F., Labouvie, E.W. y Barry, D. (2005). Short-Term Neuropsychological Recovery in Clients with Substance Use Disorders. Alcoholism: Clinical and Experimental Research, 29, 367–377.
Berking, M., Margraf, M., Ebert, D., Wupperman, P., Hofmann, S. G. y Junghanns, K. (2011). Deficits in emotion-regulation skills predict alcohol use during and after cognitive–behavioral therapy for alcohol dependence. Journal of Consulting and Clinical Psychology, 79, 307. doi:10.1037/a0023421.
Bernardin, F., Maheut-Bosser, A. y Paille, F. (2014). Cognitive impairments in alcohol-dependent subjects. Frontiers in Psychiatry, 5. doi:10.3389/fpsyt.2014.00078.
Burgess, P. W. y Shallice, T. (1997). The hayling and brixton tests. Bury St Edmunds: Thames Valley Test Company.
Cambridge Cognition Ltd. (2012). CANTABeclipse Test Administration Guide. Cambridge: Cambridge Cognition Limited.
Cao, Y., Willett, W. C., Rimm, E. B., Stampfer, M. J. y Giovannucci, E. L. (2015). Light to moderate intake of alcohol, drinking patterns, and risk of cancer: results from two prospective US cohort studies. BMJ, 351, h4238. doi:10.1136/bmj.h4238.
Cho, E., Lee, J. E., Rimm, E. B., Fuchs, C. S. y Giovannucci, E. L. (2012). Alcohol consumption and the risk of colon cancer by family history of colorectal cancer. The American Journal of Clinical Nutrition, 95, 413-419. doi:10.3945/ajcn.111.022145.
Clark, L., Dombrovski, A. Y., Siegle, G. J., Butters, M. A., Shollenberger, C. L., Sahakian, B. J. y Szanto, K. (2011). Impairment in risk-sensitive decision-making in older suicide attempters with depression. Psychology and Aging, 26, 321. doi:10.1037/a0021646
Del Ser Quijano, T., Sanchez Sánchez, F., Garcia de Yebenes, M.J., Otero Puime, A., Zunzunegui, M.V. y Muñoz, D. (2004). Versión española del Test de los 7 Minutos. Datos normativos de una muestra poblacional de ancianos de más de 70 años. Neurología, 19, 344-358.
Erickson, C.K. y White, W.L. (2009). The neurobiology of addiction recovery. Alcohol Treatment Quartely, 27, 338-345. doi:10.1080/07347320903014255.
Fein, G., Torres, J., Price, L. J. y Di Sclafani, V. (2006). Cognitive performance in long-term abstinent alcoholic individuals. Alcoholism: Clinical and Experimental Research, 30, 1538-1544. doi:10.1111/j.1530-0277.2006.00185.x.
Frías-Torres, C., Moreno-España, J., Ortega, L., Barrio, P., Gual, A. y Teixidor López, L. (2018). Remediation therapy in patients with alcohol use disorders and neurocognitive disorders: A Pilot Study. Adicciones, 30, 93-100. doi:10.20882/adicciones.757.
Grynberg, D., Maurage, P. y Nandrino, J. L. (2017). Preserved affective sharing but impaired decoding of contextual complex emotions in alcohol dependence. Alcoholism: Clinical and Experimental Research, 41, 779-785. doi:10.1111/acer.13330.
Gutnik, L. A., Hakimzada, A. F., Yoskowitz, N. A. y Patel, V. L. (2006). The role of emotion in decision-making: A cognitive neuroeconomic approach towards understanding sexual risk behavior. Journal of Biomedical Informatics, 39, 720-736. doi:10.1016/j.jbi.2006.03.002.
Heaton, R. K., Chelune, G. J., Talley, J. L., Kay, G. G. y Curtiss, G. (1993). Wisconsin card sort test manual: Revised and expanded. Odessa, FL: Psychological Assessment Resources. Odessa, FL: Psychological Assessment Resources.
Kish, G.B., Hagen, J.M., Woody, M.M. y Harvey, H.L. (1980). Alcoholics’ recovery from cerebral impairment as a function of duration of abstinence. Journal of Clinical Psychology, 36, 584-589. doi:10.1002/jclp.6120360234.
Kravitz, A. V., Tomasi, D., LeBlanc, K. H., Baler, R., Volkow, N. D., Bonci, A. y Ferré, S. (2015). Cortico-striatal circuits: novel therapeutic targets for substance use disorders. Brain Research, 1628, 186-198. doi:10.1016/j.brainres.2015.03.048.
Le Berre, A. P., Fama, R. y Sullivan, E. V. (2017). Executive Functions, Memory, and Social Cognitive Deficits and Recovery in Chronic Alcoholism: A Critical Review to Inform Future Research. Alcoholism: Clinical and Experimental Research, 41, 1432-1443. doi:10.1111/acer.13431.
Lezak, M.D., Howieson, D.B. y Loring, D.W. (2004). Neuropsychological assessment. 4 ed. New York: Oxford University Press.
Maurage, P., Pesenti, M., Philippot, P., Joassin, F. y Campanella, S. (2009). Latent deleterious effects of binge drinking over a short period of time revealed only by electrophysiological measures. Journal of Psychiatry & Neuroscience, 34, 111.
Mestre, E. V., Frías, M. D. N. y Samper, P. G. (2004). La medida de la empatía: análisis del Interpersonal Reactivity Index. Psicothema, 16, 255-260.
Munro, C.A., Saxton, J. y Butters, M.A. (2000). The neuropsychological consequences of abstinence among older alcoholics: a cross-sectional study. Alcoholism: Clinical and Experimental Research, 24, 1510-1516. doi:10.1111/j.1530-0277.2000.tb04569.x.
Nowakowska-Domagała, K., Jabłkowska-Górecka, K., Mokros, Ł., Koprowicz, J. y Pietras, T. (2017). Differences in the verbal fluency, working memory nd executive functions in alcoholics: Short-term vs. long-term abstainers. Psychiatry Research, 249, 1-8. doi:10.1016/j.psychres.2016.12.034.
Oscar-Berman, M., Valmas, M. M., Sawyer, K. S., Ruiz, S. M., Luhar, R. B. y Gravitz, Z. R. (2014). Profiles of impaired, spared, and recovered neuropsychological processes in alcoholism. Handbook of Clinical Neurology, 125, 183. doi:10.1016/B978-0-444-62619-6.00012-4.
Pedrero-Pérez, E. J., Ruiz-Sánchez de León, J. M., Llanero-Luque, M., Rojo-Mota, G., Olivar-Arroyo, A. y Puerta-García, C. (2009). Sintomatología frontal en adictos a sustancias en tratamiento mediante la versión española de la escala de comportamiento frontal. Revista de Neurología, 48, 624-631.
Pelletier, S., Nalpas, B., Alarcon, R., Rigole, H. y Perney, P. (2016). Investigation of Cognitive Improvement in Alcohol-Dependent Inpatients Using the Montreal Cognitive Assessment (MoCA) Score. Journal of Addiction, 1539096. doi:10.1155/2016/1539096.
Pfefferbaum, A., Adalsteinsson, E. y Sullivan, E. V. (2006). Dysmorphology and microstructural degradation of the corpus callosum: Interaction of age and alcoholism. Neurobiology of Aging, 27, 994-1009. doi:10.1016/j.neurobiolaging.2005.05.007.
Pfefferbaum, A., Sullivan, E. V., Mathalon, D. H., Shear, P. K., Rosenbloom, M. J. y Lim, K. O. (1995). Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcoholism: Clinical and Experimental Research, 19, 1177-1191. doi:10.1111/j.1530-0277.1995.tb01598.x.
Rosenbloom, M.J., O’Reilly, A., Sassoon, S.A., Sullivan, E.V. y Pfefferbaum, A. (2005). Persistent cognitive deficits in community-treated alcoholic men and women volunteering for research: limited contribution from psychiatric comorbidity. Journal of Studies on Alcohol and Drugs, 66, 254–265. doi:10.15288/jsa.2005.66.254.
Ruiz-Sánchez de León, J. M., Pedrero-Pérez, E. J., Rojo-Mota, G., Llanero-Luque, M. y Puerta-García, C. (2011). Propuesta de un protocolo para la evaluación neuropsicológica de las adicciones. Revista Neurología, 53, 483-93.
Scoccianti, C., Cecchini, M., Anderson, A. S., Berrino, F., Boutron-Ruault, M. C., Espina, C.,... Wiseman, M. (2016). European Code against Cancer 4th Edition: Alcohol drinking and cancer. Cancer Epidemiology, 45, 181-188. doi:10.1016/j.canep.2016.09.011.
Seisdedos, N. (2004). Test de atención d2. Madrid: TEA Ediciones.
Spreen, O. y Strauss, E. (1991). Controlled oral word association (word fluency). Spreen O, Strauss E. A compendium of neuropsychological tests. Oxford: Oxford University Press, 219-227.
Staples, M. C. y Mandyam, C. D. (2016). Thinking after drinking: impaired hippocampal-dependent cognition in human alcoholics and animal models of alcohol dependence. Frontiers in Psychiatry, 7. doi:10.3389/fpsyt.2016.00162.
Stasiewicz, P. R., Bradizza, C. M., Gudleski, G. D., Coffey, S. F., Schlauch, R. C., Bailey, S. T.,... Gulliver, S. B. (2012). The relationship of alexithymia to emotional dysregulation within an alcohol dependent treatment sample. Addictive Behaviors, 37, 469-476. doi:10.1016/j.addbeh.2011.12.011.
Stavro, K., Pelletier, J. y Potvin, S. (2013). Widespread and sustained cognitive deficits in alcoholism: a meta-analysis. Addiction Biology, 18, 203-213.
Sullivan, E. V., Rosenbloom, M. J., Lim, K. O. y Pfefferbaum, A. (2000a). Longitudinal changes in cognition, gait, and balance in abstinent and relapsed alcoholic men: relationships to changes in brain structure. Neuropsychology, 14, 178–188. doi:10.1037/0894-4105.14.2.178.
Sullivan, E.V., Rosenbloom, M.J. y Pfefferbaum, A. (2000b). Pattern of motor and cognitive deficits in detoxified alcoholic men. Alcoholism: Clinical and Experimental Research, 24, 611–621.
Valmas, M. M., Mosher Ruiz, S., Gansler, D. A., Sawyer, K. S. y Oscar-Berman, M. (2014). Social cognition deficits and associations with drinking history in alcoholic men and women. Alcoholism: Clinical and Experimental Research, 38, 2998-3007.
Wechsler D. (1999). Escala de inteligencia Wechsler para adultos (WAIS-III). 3 ed. Madrid: TEA.
Wechsler, D. (1997). Wechsler memory scale (WMS-III) (Vol. 14). San Antonio, TX: Psychological Corporation.
Wilson, B. A., Alderman, N., Burgess, P. W., Emslie, H. y Evans, J. J. (1996). Behavioural assessment of the Dysexecutive Syndrome. Bury St. Edmunds, UK: Thames Valley Test Company.
Yohman, J. R., Parsons, O. A. y Leber, W. R. (1985) Lack of recovery in male alcoholics’ neuropsychological performance one year after treatment. Alcoholism: Clinical and Experimental Research, 9, 114–117. doi:10.1111/j.1530-0277.1985.tb05530.x.
Zywiak, W.H., Westerberg V.S., Connors G.J. y Maisto S.A. (2003). Exploratory findings from the Reasons for Drinking Questionnaire. Journal of Substance Abuse Treatment, 25, 287–292. doi:10.1016/S0740-5472(03)00118-1.


