Variation in the pattern of synthetic cannabinoid use by a female patient during 2018

Abstract

The consumption of synthetic cannabinoids is a growing problem. In Spain, the number of seizures and poisonings related to these new psychoactive substances (NPS) is less than in the rest of Europe. However, the analysis of herbal mixtures sold in smart shops and web pages reflects that these products are indeed reaching the Spanish population. In this work, the consumption pattern of synthetic cannabinoids in the city of Valencia (Spain) is studied, through the analysis of herbal preparations for smoking, cigarettes and urine samples of potential consumers collected in different Addictive Behavior Units (ABUs) ) from the city. Different products available at a local smart-shop were analyzed, as well as herbs collected in the UCAs. Mass spectrometric analysis revealed the presence of the synthetic cannabinoids XLR-11 and UR-144. The urine of a patient from the ABU, treated for alleged cannabis use, who showed signs of use, was also analysed, although routine analysis gave negative results. Metabolites of these cannabinoids were found, previously reported in the literature. Following the summer of 2018, new herb and cigar samples were seized, identifying the dangerous cannabinoid 5F-ADB. The main metabolites reported for this synthetic cannabinoid were also detected in the urine samples, and this compound was also identified in a new herb from the smart shop. It is interesting to note that this change in consumption coincides with the ban on XLR-11 in Spain in July 2018, illustrating how the legislation on these compounds affects their availability and, therefore, their consumption pattern.