Adolescent cannabis consumption and schizophrenia: epidemiological and experimental evidences
DOI:
https://doi.org/10.20882/adicciones.178Keywords:
cannabis, adolescencia, psicosis, esquizofrenia, cerebroAbstract
Marijuana is consistently the most widely used illicit drug among teenagers and most users first experiment it in adolescence. Adolescence is a critical period between childhood and adulthood, including not only reproductive maturation, but also cognitive, emotional and social maturation. In this period adolescent brain is still in transition differing anatomically and neurochemically from the adult’s one. The endocannabinoid system is an important determinant for cerebral maturation, therefore its strong stimulation by the delta-9- tetrahydrocannabinol, that acts through the endocannabinoid system, might lead to subtle but lasting neurobiological changes that can affect adult brain functions and behaviour. We summarize the more recent researches investigating the relationships between adolescent exposure to cannabinoids and increased risk for psychotic disease such as schizophrenia, as highlighted by both human and animal studies. Epidemiological evidence suggests that cannabis use is a risk factor for schizophrenia, and an exacerbation of symptoms and worsening of the schizophrenic prognosis may occur in individuals with a predisposition for schizophrenia. The characteristic of adolescent brain probably makes it more vulnerable to cannabis effect producing psychotic like symptoms and possibly cause schizophrenia.References
Piomelli D. The molecular logic of endocannabinoid signalling Nat Rev Neurosci 2003; 4: 873-84.
Harkany T, Mackie K. & Doherty P. Wiring and firing neuronal networks: endocannabinoids take center stage. Curr Opin Neurobiol 2008; 18: 338-45.
Berghuis SP, Dobszay MB, Wang X, Spano S., Ledda F, Sousa KM
et al. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc Natl Acad Sci U S A 2005; 102: 19115-20.
D’Souza DC, Sewell RA, Ranganathan M. Cannabis and psychosis/schizophrenia: human studies. Eur Arch Psychiatry. Clin Neurosci 2009; 259: 413-31.
Sewell RA, Ranganathan M, D’Souza, DC. Cannabinoids and psychosis. Int Rev Psychiatry 2009; 21: 152-62.
Macleod J, Oakes R, Copello A, Crome I, Egger M, Hickman M et
al. Psychological and social sequelae of cannabis and other illicit drug use by young people: a systematic review of longitudinal, general population studies. Lancet 2004; 363:1579-88.
Ajdacic-Gross V, Lauber C, Warnke I, Haker H, Murray RM, Rossler W, Changing incidence of psychotic disorders among the young in Zurich. Schizophr Res 2007, 95:9-18.
Stefanis NC, Delespaul P, Henquet C, Bakoula C, Van Os J. Early adolescent cannabis exposure and positive and negative dimensions of psychosis. Addiction 2004; 99: 1333-41.
Schifman J, Nakamura B, Earleywine M, Labrie J Symptoms of schizotypy precede cannabis use. Psychiatry Res 2005; 134:37-42.
Barkus E., Lewis S. Schizotypy and psychosis-like experiences from recreational cannabis in a non-clinical sample. Psychol Med 2008; 38:1267-76.
Sugranyes G, Flamarique I, Parellada E, Baeza I, Goti J, Fernández-Egea E, Bernardo M. Cannabis use and age of diagnosis of schizophrenia. Eur Psychiatry 2009; 24: 282-6.
Realini N, Rubino T,. Parolaro D. Neurobiological alterations at adult age triggered by adolescent exposure to cannabinoids. Pharmacological Research 2009; 60: 132–8.
Schneider M, Koch M. Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats. Neuropsychopharmacology 2003; 28: 1760-69.
Schneider, M, Koch M. The effect of chronic peripubertal cannabinoid treatment on deficient object recognition memory in rats after neonatal mPFC lesion. Eur Neuropsychopharmacol 2007; 17: 180-6.
Vigano D, Guidali C, Petrosino S, Realini N, Rubino T, Di Marzo V, Parolaro D. Involvement of the endocannabinoid system in phencyclidine-induced cognitive deficits modelling schizophrenia. Int J Neuropsychopharmacol 2009; 12: 599-614.
Guidali C, Viganò D, Petrosino S, Zamberletti E, Realini N, Binelli et al. Cannabinoid CB1 receptor antagonism prevents neurochemical and behavioural deficits induced by chronic phencyclidine. Int J Neuropsychopharmacol 2010 Mar 3:1-12. [Epub ahead of print].
Malone DT, Jongenan D, Taylor DA. The effect of cannabidiol on
open field behaviours induced by Δ9-tetrahydrocannabinol in rats. Pharmacol Biochem Behav 2009; 93: 91-6.
Malone DT, Taylor DA. The effect of Delta9-tetrahydrocannabinol
on sensorimotor gating in socially isolated rats. Behav Brain Res 2006; 166:101-9.
Sciolino NR, Bortolato M, Eisenstein SA, Fu J, Oveisi F, Hohmann AG et al. Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats. Neuroscience 2010; 168: 371-86.
Rubino T, Realini, N, Braida D, Guidi S, Capurro V, Vigano D et al.. Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood. Hippocampus 2009; 8:763-72.
Rubino T, Realini, N, Braida D Alberio T, Capurro V, Vigano D et al. The depressive phenotype induced in adult female rats by adolescent exposure to THC is associated with cognitive impairment and altered neuroplasticity in the prefrontal cortex. Neurotox Res 2009; 15: 291-302.
Suarez J, Llorente R, Romero-Zerbo SY, Mateos B, Bermudez-Silva F, De Fonseca F.R. et al Early maternal deprivation induces gender dependent changes on the expression of hippocampal CB(1) and CB(2) cannabinoid receptors of neonatal rats. Hippocampus 2009; 19: 623-32.
Ishiguro H, Horiuchi Y, Ishikawa M, Koga M, Imai K, Suzuki Y, et al Brain Cannabinoid CB2 Receptor in Schizophrenia. Biol Psychiatry 2010; 67: 974-82.
Leweke FM, Giuffrida A, Wurster U, Emrich HM, Piomelli D. Elevated endogenous cannabinoids in schizophrenia. Neuro Report 1999; 10: 1665-9.
Leweke FM, Koethe D. Cannabis and psychiatric disorders: it is not only addiction. Addict Biol 2008; 13: 264-75.
Caspi A, Moffitt TE, Cannon M, Macclay J, Murray R, Harrington
H et al. Moderation of the Effect of Adolescent-Onset Cannabis Use on Adult Psychosis by a Functional Polymorphism in the Catechol O-Methyltransferase Gene: Longitudinal Evidence of a Gene X Environment Interaction. Biological Psychiatry 2005; 57:1117-27.
Malone DT, Jongegan D, Taylor DA. The effect of cannabidiol on
open field behaviours induced by Δ9-tetrahydrocannabinol in rats. Pharmacol Biochem Behav 2009; 93: 91-96.
Leweke FM, Schneider U, Radwan M, Schmidt E, Emrich HM. Different effects of nabilone and cannabidiol on binocular depth inversion in Man. Pharmacol Biochem Behav 2000; 66:175-81.
