Healthcare professionals’ perception of prolonged-release buprenorphine in opioid use disorder. FOLIPRO Study

Authors

  • Rodrigo Oraá Gil Red de Salud Mental Bizkaia. Osakidetza. Red de salud mental – ISS Biocruces Bizkaia
  • Diego Sucunza Guibert Camurus SL, Madrid, España
  • María Yébenes Cortés Pharmacoeconomics & Outcomes Research Iberia (PORIB), Madrid
  • Miguel Ángel Casado Gómez Pharmacoeconomics & Outcomes Research Iberia (PORIB), Madrid
  • José Joaquín Antón Basanta Presidente de la Sociedad Española de Sanidad Penitenciaria (SESP). Médico en Centro Penitenciario Albolote Granada
  • Francisco Pascual Pastor Presidente Sociedad Científica Española para el Estudio del Alcohol, el Alcoholismo y las otras Toxicomanías, Socidrogalcohol. Coordinador Unidad Conductas Adictivas Alcoi, Alicante
  • Carlos Roncero Health Science Faculty, European University Miguel de Cervantes (UEMC), Valladolid. Network of Research In Primary care of Addictions (RIAPAD). Psychiatric Unit, School of Medicine, University of Salamanca. Institut of Biomedicine (IBSAL), Salamanca, Spain.

DOI:

https://doi.org/10.20882/adicciones.2007

Keywords:

Opioid Use Disorder

Abstract

The aim of the FOLIPRO study was to determine the satisfaction and expectations of healthcare professionals with experience in opioid use disorders (OUD) with prolonged-release buprenorphine (PRB). FOLIPRO was designed as an anonymous, cross-sectional, multicenter survey aimed at professionals from addiction centers (AC) and penitentiary centers in Spain. The survey collected characteristics of the AC and the healthcare professionals. Possible barriers associated with the prescription of PRB in OUD treatment were also identified. Seventy-four questionnaires were received from 45 different centers. More than half of the centers, 51.1%, were outpatient methadone (MTD) dispensing centers and 31.1% were penitentiary centers. 68.5% of the participants had experience with PRB, which exceeded 6 months in 58.3% of the cases. 31.5% stated that they had no experience, 40% of them mainly due to reimbursement criteria for PRB. Regarding prescribing/administration issues, professionals reported greater satisfaction with PRB compared to MTD and buprenorphine/naloxone (SL-BPN/NX). According to healthcare professionals, bureaucracy, lack of knowledge of some prescribers, and patient refusal due to fear of opioid withdrawal were the main barriers described in for prescribing PRB. The results of the study show high satisfaction among healthcare professionals with PRB, positioning PRB as a valuable treatment option.

References

Andraka-Christou, B., Page, C., Schoebel, V., Buche, J. y Haffajee, R. L. (2022). Perceptions of buprenorphine barriers and efficacy among nurse practitioners and physician assistants. Addiction science & clinical practice, 17(1), 43. https://doi.org/10.1186/s13722-022-00321-6

Andrilla, C. H. A., Jones, K. C. y Patterson, D. G. (2020). Prescribing practices of nurse practitioners and physician assistants waivered to prescribe buprenorphine and the barriers they experience prescribing buprenorphine. The Journal of rural health: official journal of the American Rural Health Association and the National Rural Health Care Association, 36(2), 187–195.

Bell, J. y Strang, J. (2020). Medication treatment of opioid use disorder. Biological psychiatry, 87(1), 82–88. https://doi.org/10.1016/j.biopsych.2019.06.020

Cioe, K., Biondi, B. E., Easly, R., Simard, A., Zheng, X. y Springer, S. A. (2020). A systematic review of patients’ and providers’ perspectives of medications for treatment of opioid use disorder. Journal of substance abuse treatment, 119, 108146. https://doi.org/10.1016/j.jsat.2020.108146

DeFlavio, J. R., Rolin, S. A., Nordstrom, B. R. y Kazal, L. A. Jr. (2015). Analysis of barriers to adoption of buprenorphine maintenance therapy by family physicians. Rural and remote health, 15, 3019. https://doi.org/10.22605/RRH3019

Dematteis, M., Auriacombe, M., D’Agnone, O., Somaini, L., Szerman, N., Littlewood, R., Alam, F., Alho, H., Benyamina, A., Bobes, J., Daulouede, J. P., Leonardi, C., Maremmani, I., Torrens, M., Walcher, S. y Soyka, M. (2017). Recommendations for buprenorphine and methadone therapy in opioid use disorder: A European consensus. Expert opinion on pharmacotherapy, 18(18), 1987–1999. https://doi.org/10.1080/14656566.2017.1409722

European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) (2023). European Drug Report 2023: Trends and developments, https://www.emcdda.europa.eu/publications/european-drug-report/2023_en

European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) (2021). Opioids: health and social responses. Health and social responses to drug problems: A European guide. https://www.emcdda.europa.eu/publications/mini-guides/opioids-health-and-social-responses_en

Knudsen, H. K., Brown, R., Jacobson, N., Horst, J., Kim, J. S., Kim, H., Madden, L. M., Haram, E. y Molfenter, T. (2021). Prescribers’ satisfaction with delivering medications for opioid use disorder. Substance abuse treatment, prevention, and policy, 16(1), 78. https://doi.org/10.1186/s13011-021-00413-7

Lin, L. A., Lofwall, M. R., Walsh, S. L., Gordon, A. J. y Knudsen, H. K. (2018). Perceptions and practices addressing diversion among US buprenorphine prescribers. Drug and alcohol dependence, 186, 147–153. https://doi.org/10.1016/j.drugalcdep.2018.01.015

López-Briz, E. y Giner García, R. (2021). Buprenorfina subcutánea de liberación prolongada en el tratamiento de la dependencia a opiáceos. Rev esp de drogodependencias, 46 (1), 104-109.

Louie, D. L., Assefa, M. T. y McGovern, M. P. (2019). Attitudes of primary care physicians toward prescribing buprenorphine: A narrative review. BMC family practice, 20(1), 157. https://doi.org/10.1186/s12875-019-1047-z

Marco, A., López-Burgos, A., García-Marcos, L., Gallego, C., Antón, J.J. y Errasti, A. (2013). ¿Es necesario disponer de tratamientos con Buprenorfina/Naloxona para los presos dependientes de opiáceos? Rev Esp Sanid Penit, 15, 105-113. ISSN 2013-6463.

Mendoza, S., Rivera-Cabrero, A. S. y Hansen, H. (2016). Shifting blame: Buprenorphine prescribers, addiction treatment, and prescription monitoring in middle-class America. Transcultural psychiatry, 53(4), 465–487. https://doi.org/10.1177/1363461516660884

Pascual, F. S., Muñoz, A., Oraa, R., Flórez, G., Notario, P., Seijo, P., Gonzalvo, B., Assaf, C., Gómez, M. y Casado, M. Á. (2022). Perception of a new prolonged-release buprenorphine formulation in patients with opioid use disorder: The PREDEPO study. European addiction research, 28(2), 143–154. https://doi.org/10.1159/000520091

Pascual Pastor, F., Muñoz, Á., Oraa, R., Flórez, G., Notario, P., Seijo, P., Gonzalvo, B., Assaf, C., Gómez, M. y Casado, M. Á. (2023). Patients’satisfaction and experience in treatment with opioid substitution therapy in Spain. The PREDEPO study. Satisfacción y experiencia de pacientes en tratamiento con sustitutivos opioides en España. Estudio PREDEPO. Adicciones, 35(4), 433–444. http://dx.doi.org/10.20882/adicciones.1684

Roncero, C., Domínguez-Hernández, R., Díaz, T., Fernández, J. M., Forcada, R., Martínez, J. M., Seijo, P., Terán, A. y Oyagüez, I. (2015). Management of opioid-dependent patients: Comparison of the cost associated with use of buprenorphine/naloxone or methadone, and their interactions with concomitant treatments for infectious or psychiatric comorbidities. Adicciones, 27(3), 179–189.

Roncero, C., Vega, P., Grau-López, L., Mesías, B., Barral, C., Basurte-Villamor, I., Rodríguez-Cintas, L., Martinez-Raga, J., Piqué, N., Casas, M. y Szerman, N. (2016). Relevant differences in perception and knowledge of professionals in different Spanish autonomous communities regarding availability of resources for patients with dual disorders. Actas españolas de psiquiatria, 44(1), 1–12.

Strang, J., Volkow, N. D., Degenhardt, L., Hickman, M., Johnson, K., Koob, G. F., Marshall, B. D. L., Tyndall, M. y Walsh, S. L. (2020). Opioid use disorder. Nature reviews. Disease primers, 6(1), 3. https://doi.org/10.1038/s41572-019-0137-5

Suzuki, J., Connery, H. S., Ellison, T. V. y Renner, J. A. (2014). Preliminary survey of office-based opioid treatment practices and attitudes among psychiatrists never receiving buprenorphine training to those who received training during residency. The American journal on addictions, 23(6), 618–622. https://doi.org/10.1111/j.1521-0391.2014.12143.x

Vorspan, F., Hjelmström, P., Simon, N., Benyamina, A., Dervaux, A., Brousse, G., Jamain, T., Kosim, M. y Rolland, B. (2019). What place for prolonged-release buprenorphine depot-formulation Buvidal® in the treatment arsenal of opioid dependence? Insights from the French experience on buprenorphine. Expert opinion on drug delivery, 16(9), 907–914. https://doi.org/10.1080/17425247.2019.1649252

Yarborough, B. J., Stumbo, S. P., McCarty, D., Mertens, J., Weisner, C. y Green, C. A. (2016). Methadone, buprenorphine and preferences for opioid agonist treatment: A qualitative analysis. Drug and alcohol dependence, 160, 112–118. https://doi.org/10.1016/j.drugalcdep.2015.12.031

Published

2025-03-25

Issue

Section

Originals