Research on Etiological aspects of Dual Pathology
DOI:
https://doi.org/10.20882/adicciones.210Keywords:
Dual Pathology, Substance-use Disorders, Personality Disorders, Family Dynamics, Behaviour Disorders, Family Psychopathologic HistoryAbstract
Introduction: It is important to assess the interaction between family psychopathologic history (FH), family dynamics (FD), behavior disorders, substance-use disorders and personality disorders (PD). Methodology: Cross-sectional design. The sample was made up of 350 subjects with substance-use disorders who were assessed for FH including alcoholism and substance-use disorders through an interview; for substance use via a questionnaire; for FD; for PD using the International Personality Disorder Examination (IPDE); for behavior problems in adolescence; and for disocial disorder. Correlated variables were included in logistic regression models. Results: Early age of onset for substance use is related to FH of substanceuse disorders and poorer FD. FH of alcoholism, substance-use disorders and psychiatric disorders are related to poorer FD. Early age of onset for substance use, FH and a disruptive FD are related to behavior problems and disocial disorder. Early age of onset for substance use, FH, disruptive FD, behavior problems and disocial disorder are related to presence of PD. Logistic regression predicted the presence of PD by age of onset for use of methadone (CI(95):1.005/3.222; p=0.048) and of other opiates (CI(95):0.864/0.992;p=0.028). FH score in alcoholism predicted Borderline Personality Disorder (CI(95):1.137- 2.942; p=0.013), and age of onset of cocaine use predicted Antisocial Personality Disorder (CI(95):0.864/0.992; p=0.028). Conclusions: FH of substance use and own use predict the presence of some PDs.References
Hill J. Early identification of individuals at risk for antisocial personality disorder. Br J Psychiatry 2003; 44: 11-4.
Kim-Cohen J, Caspi A, Moffitt TE, Harrington H, Milne BJ, Poulton R. Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort. Arch Gen Psychiatry 2003; 60: 709-17.
Ramklint M, von Knorring Al, von Knorring L, Ekselius L. Personality disorders in former child psychiatric patients. Eur Child Adolesc Psychiatry 2002; 11: 289-95.
Vizard E, French L, Hickey L, Blandon E. Severe personality disorder
emerging in childhood: a proposal for a new developmental disorder. Crim Behav Ment Health 2004; 14: 17-28.
Boys A, Farrell M, Taylor C, Marsden J, Goodman R, Brugha T et al. Developmental, family, and ethnic influences on adolescent alcohol usage: a growth curve approach. J Fam Psychol 2001; 15: 301-14.
Clark DB, Pollock N, Bukstein OG, Mezzich AC, Bromberger JT, Donovan JE. Gender and comorbid psychopathology in adolescents with alcohol dependence. Addict Behav 1997; 36:1195-203.
Casas M, Guardia J. Patología psiquiátrica asociada al alcoholismo.
Adicciones 2002; 14: 195-219.
Clark DB, Kirisci L, Moss HB. Early adolescent gateway drug use in
sons of fathers with substance use disorders. Addict Behav 1998; 23: 561-6.
Clark DB, Kirisci L, Tarter RE. Adolescent versus adult onset and
the development of substance use disorders in males. Drug Alcohol Depend 1998; 49: 115-21.
Coffey C, Carlin JB, Lynskey M, Li N, Patton GC. Adolescent precursors of cannabis dependence: findings from the Victorian Adolescent Health Cohort Study. Br J Psychiatry 2003; 182: 330-6.
Ensminger ME. Sexual activity and problem behavior among black, urban adolescents. Child Development 1990; 61: 2032-46.
Hser YI, Grella CE, Collins C, Teruya C. Drug-use initiation and conduct disorder among adolescents in drug treatment. J Adolesc 2003; 26: 331-45.
Modestin J, Matutat B, Wurmle O. Antecedents of opiod dependence and personality disorder: attention-deficit/hyperactivity disorder and conduct disorder. Eur Arch Psychiatry Clin Neurosci 2001; 251: 42-7.
Donovan JE, Jessor R. Structure of problem behavior in adolescence and young adulthood. J Consult Clin Psychol 1985; 53: 890-904.
Donovan JE, Jessor R, Costa FM. Syndrome of problem behavior in
adolescence: A replication. J Consult Clin Psychol 1988; 56: 762-65.
Widom CS. The cycle of violence. Science 1989; 244: 160-6.
Rutter M, Giller H, Hagell A. Antisocial Behavior by Young people.
Cambridge: Cambridge University Press, 1998.
Bray JH, Adams GJU, Getz JG, Baer PE. Developmental, family, and
ethnic influences on adolescent alcohol usage: a growth curve approach. J Fam Psychol 2001; 15: 301-14
Holmes SE, Slaughter JR; Kashani J. Risk factors that lead to the development of conduct disorder and antisocial personality disorder. Child Psychiatry Hum Dev 2001; 31: 183-91.
Mandel HP. Conduct Disorder and under-achievement: risk factors, assessment, treatment, and prevention. New York: John Wiley & Sons Inc, 1997.
Sanz M, Iraurgi I, Martinez-Pampliega A, Cosgaya L. Conflicto marital y consumo de drogas en los hijos. Adicciones 2006; 18:39-48.
Dishion TJ, Bullock BM, Granic I. Pragmatism in modeling peer influence: dynamics, outcomes, and change processes. Dev Psychol 2002; 14: 966-81
Prinstein MJ, Boegers J, Spirito A. Adolescents and their friends’ health-risk bahavior: factors that alter or add to peer influence. J Pediatr Psychol 2001; 26: 287-98.
Duncan SC, Duncan TE, Biglan A, Ary D. Contributions of the social context to the development of adolescent substance use: a multivariate latent growth modeling approach. Drug Alcohol Depend 1998; 50: 57-71.
Mandel HP, Mandel DE). Along the path: Case histories of differentially diagnosed underachievers. Toronto: York University, ed., 1995.
Mandel HP, Marcus SI, Dean L. Could do better: Why children underachieve and what to do about it. New York: Wiley, 1995.
Olson SL. Development of conduct problems and peer rejection in preschool children: A social systems analysis. J Abnorm Child Psychol 1992; 20: 327-50.
Keenan K, Loeber R, Zhang Q, Stouthamer-Loeber M. The influence of deviant peers on the development of boys’ disruptive and delinquent behavior: A temporal analysis. Dev Psychopathol 1995; 7: 715-26.
Asher SR, Erdley CA, Gabriel SW. Peer relations. En: Rutter M, Hay L, eds. Development through life: A handbook for clinicians. Oxford: Blackwell Scientific, 1994. pp. 456-87.
Coie JD, Dodge KA. Aggression and antisocial behavior. En: Damon
W, Eisenberg N, eds. Handbook of child psychology, vol. 3: Social, emotional, and personality development, 5th ed. New York: Wiley, 1997. p. 779-862.
Dishion TJ, Patterson GR, Stoolmiller M, Skinner ML. Family, school, and behavioral antecedents to early adolescent in involvement with antisocial peers. Dev Psychol 1991; 27: 172-80.
Parker JG, Asher SR. Peer relations and later personal adjustment:
Are low-accepted children at risk? Psychol Bull 1987; 102: 357-89.
Roeser RW, Eccles JS. Schooling and mental health. En: Sameroff AJ, Lewis M, eds. Handbook of development psychopathology, 2nd ed. New York: Kluwe Academic/Plenum Press, 2000. p. 135-56.
McBurnett K, Kerckhoff C, Capasso L, Pfiffner LJ, Rathouz PJ, McCord M et al. Antisocial personality, substance abuse, and exposure to parental violence in males referred for domestic violence. Violence Vict 2001; 16: 491-506.
Greene RW, Biederma J, Zerwas S, Monuteaux MC, Goring JC, Faraone SV. Psychiatric comorbidity, family dysfunction, and social impairment in referred youth with oppositional defiant disorder. Am J Psychiatry 2002; 159: 1214-24.
Jouriles EN, Murphy CM, O´Leary. Interspousal aggression, marital
discord and child problems. J Consult Clin Psychol 1989; 57: 453-5.
Lahey BB, Hartdagen SE, Frick PJ, McBurnett K, Connor R, Hynd
GW. Conduct disorder: Parsing the confounded relation of parental divorce and antisocial personality. J Abnorm Psychol 1988; 97: 334-7.
Moss HB, Baron DA, Hardie TL, Vanyukov MM. Preadolescent children of substance-dependent fathers with antisocial personality disorder: psychiatric disorders and problem behaviours. Am J Addict 2001; 10: 269-78.
Granic I, Patterson GR. Toward a comprehensive model of antisocial development: a dynamic systems approach. Psychol Rev 2006; 113: 101-31.
Farrington DP, Hawkins JD. Predicting participation, early-onset and later persistence in officially recorded offending. Crim Behav Ment Health 1991; 1: 1-33.
McCord J. Questioning the value of punishment. Soc Probl 1991; 38: 167-79.
Haro G, Mateu C, Martinez-Raga J, Valderrama JC, Castellano M,
Cervera G. The role of personality disorders on drug dependence treatment outcomes following inpatient detoxification. Eur Psychiatry 2004; 19: 187-92.
Mateu G, Astals M, Torrens M. Comorbilidad psiquiátrica y trastorno
por dependencia de opiáceos: del diagnóstico al tratamiento. Adicciones, 2005; 17: 111-121.
Fernández JJ, Gutiérrez E. Trastornos de personalidad y dependencia
de heroína: una relación por determinar. Adicciones 2005; 17: 95-110.
Loranger AW, Sartorius N, Anfreoli A, Berger P, Buchheim P, Channabasavanna SN et al. The International Personality Disorder Examination. The World Health Organization/Alcohol, Drug Abuse, and Mental Health Administration international pilot study of personality disorders. Arch Gen Psychiatry, 1994; 51: 215-24.
Parra GR, O’Neill SE, Sher KJ. Reliability of self-reported age of substance involvement onset. Psychol Addict Behav 2003; 17: 211-8.
Tremeau F, Darreye A, Leroy B, Renckly V, Ertle S, Weibel H et al.
Personality changes in opioid-dependent subjects in a methadone maintenance treatment program. Encephale 2003; 29: 285-92.
Cacciola JS, Rutherford MJ, Alterman AI, McKay JR, Mulvaney FD.
Long-term test-retest reliability of personality disorder diagnoses in opiate dependent patients. J Personal Disord 1998; 12: 332-7.
Keller PS, Cummings EM, Davies PT. The role of marital discord and parenting in relations between parental problem drinking and child adjustment. J Child Psychol Psychiatry 2005; 46: 943-51.
Fuller BE, Chermack ST, Cruise KA, Kirsch E, Fitzgerald HE, Zucker
RA. Predictors of aggression across three generations among sons of alcoholics: relationships involving grandparental and parental alcoholism, child aggression, marital aggression and parenting practices. J Stud Alcohol 2003; 64: 472-83.
Windle M. On the discriminative validity of a family history of problem drinking index with a national sample of young adults. J Stud Alcohol 1996; 57: 378-86.
Nurnberger JJ, Wiegand R, Bucholz K, O’Connor S, Meyer ET, Reich T et al. A family study of alcohol dependence: coaggregation of multiple disorders in relatives of alcohol-dependent probands. Arch Gen Psychiatry 2004; 61: 1246-56.
Hicks BM, Krueger RF, Iacono WG, McGue M, Patrick CJ. Family
transmission and heritability of externalizing disorders: a twinfamily study. Arch Gen Psychiatry 2004; 61: 922-8.
Merikangas KR, Stolar M, Stevens DE, Goulet J, Preisig MA, Fenton
B et al. Familial transmission of substance use disorders. Arch Gen Psychiatry 1998; 55: 964-5.
Kaplow JB, Curran PJ, Dodge KA. Conduct Problems Prevention Research Group. Child, parent, and peer predictors of early-onset substance use: a multisite longitudinal study. J Abnorm Child Psychol 2002; 30: 199-216.
Caudill BD, Hoffman JA, Hubbard RL, Flynn PM, Luckey JW. Parental history of substance abuse as a risk factor in predicting crack smokers’ substance use, illegal activities, and psychiatric status. Am J Drug Alcohol Abuse 1994; 20: 341-54.
Nickell AD, Waudby CJ, Trull TJ. Attachment, parental bonding and borderline personality disorder features in young adults. J Personal Disord 2002; 16: 148-59.
Golomb A, Ludolph P, Westen D, Block MJ, Maurer P, Wiss FC. Maternal empathy, family chaos, and the etiology of borderline personality disorder. J Am Psychoanal Assoc 1994; 42: 525-48.
De Bellis MD. Developmental traumatology: a contributory mechanism for alcohol and substance use disorders. Psychoneuroendocrinology
; 27: 155-70.
Brems C, Namyniuk L. The relationship of childhood abuse history
and substance use in an Alaska sample. Subst Use Misuse 2002; 37: 473-94.
Lobbestael J, Arntz A, Sieswerda S. Schema modes and childhood
abuse in borderline and antisocial personality disorders. J Behav Ther Exp Psychiatry 2005; 36: 240-53.
Zanarini MC. Childhood experiences associated with the development of borderline personality. Psychiatr Clin North Am 2000; 23: 89-101.
Brown GR, Anderson B. Psychiatric morbidity in adult inpatients with childhood histories of sexual and physical abuse. Am J Psychiatry 1992; 149: 578.
Kuritarne IS. Childhood trauma in the etiology of borderline personality disorder. Psychiatr Hung 2005; 20: 256-70.
Schubiner H, Tzelepis A, Milberger S, Lockhart N, Kruger M, Kelley BJ et al. Prevalence of attention-deficit/hyperactivity disorder and conduct disorder among substance abusers. J Clin Psychiatry 2000; 61: 244-51.
King SM, Iacono WG, McGue M. Childhood externalizing and internalizing psychopathology in the prediction of early substance use. Addiction 2004; 99: 1548-59.
Hahesy AL, Wilens TE, Biederman J, Van Patten SL, Spencer T. Temporal association between childhood psychopathology and substance use disorders: findings from a sample of adults with opioid or alcohol dependency. Psychiatry Res 2002; 109: 245-53.
Taylor J, Malone S, Iacono WG, McGue M. Development of substance dependence in two delinquency subgroups and nondelinquents from a male twin sample. J Am Acad Child Adolesc Psychiatry 2002; 41: 386-93.
Kuperman S, Schlosser SS, Kramer JR, Bucholz K, Hesselbrock V,
Reich T et al. Developmental sequence from disruptive behavior diagnosis to adolescent alcohol dependence. Am J Psychiatry 2001; 158: 2022-6.
Muñoz-Rivas MJ, Graña JL, Peña ME, Andreu JM. Influencia de la conducta antisocial en el consumo de drogas ilegales en población adolescente. Adicciones 2003; 3:313-320.
Franken IH, Hendriks VM. Early-onset of illicit substance use is associated with greater axis-II comorbidity, not with axis-I comorbidity. Drug Alcohol Depend 2000; 59: 305-8.
Gasperini M, Battaglia M, Scherillo P, Sciuto G, Diaferia G, Bellodi L. Morbidity risk for mood disorders in the families of borderline patients. J Affect Disord 1991; 21: 265-72.
Suzuki K. Psychiatric illnesses in adolescents of alcoholic parents.
Seishin Shinkeigaku Zasshi 1990; 92: 79-88.
Haver B. Female alcoholics. The relationship between family history of alcoholism and outcome 3-10 years after treatment. Acta Psychiatr Scand 1987; 76: 21-7.
Loranger AW, Tulis EH. Family history of alcoholism in borderline
personality disorder. Arch Gen Psychiatry 1985; 42: 153-7.
Ridenour TA, Cottler LB, Robins LN, Compton WM, Spitznagel EL,
Cunningham-Williams RM. Test of the plausibility of adolescent substance use playing a causal role in developing adulthood antisocial behavior. J Abnorm Psychol 2002; 111: 144-55.
