Search for a pharmaceutical for marijuana dependency
DOI:
https://doi.org/10.20882/adicciones.351Keywords:
marijuana, δ-9-tetrahydrocannabinol, rimonabant, uptake-inhibitors, endocannabinoid systems, anandamideAbstract
No kind of pharmaceutical has been found that responds adequately to the demands for treatment being made by an increasing number of marijuana users. There have, however, been trials of compounds currently being used to alleviate the symptoms associated with abstinence from other drugs, but the results have not been positive in this case. Among compounds acting as agonists or antagonists of cannabinoid receptors, only the controlled use of -9-tetrahydrocannabinol (THC) has produced interesting results in treating abstinence. But, there are limitations on the use of THC, as it does not reduce the craving. There is a new line of research relating to the function of the endocannabinoid system, based on the design of compounds that increase the half-life of anandamide in the brain of patients undergoing treatment.References
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