Neuroadaptative changes in dopaminergic and glutamatergic receptor subtypesafter extinction of cocaine self-administration behavior
DOI:
https://doi.org/10.20882/adicciones.578Keywords:
self-administration behavior, extinction behavior, cocaine, glutamate, dopamine, receptors, neuroadaptative changes, drug abuse, relapseAbstract
There are different factors that could participate in relapse to drug addiction. These factors are characterized as exogenous and endogenous. It is clear that exogenous factors such as peer groups, poor socioeconomical level...etc, are relevant to induce relapse in drug addiction. However, the role of endogenous factors such as disregulation of neurotransmitter systems, subject’s personality....etc, are less understood. In this work we present data that suggest that, after extinction of cocaine self-administration in rats, there are neuroadaptative changes in dopaminergic and glutamatergic brain receptors in cerebral areas involved in cocaine reinforcing effects. These neuroadaptations are more permanent and long lasting in dopaminergic receptors compared to glutamatergic receptors. The results of this study suggest that specific neuroadaptative changes in glutamatergic and dopaminergic receptor systems might be involved in negative states of cocaine withdrawal and facilitate vulnerability to cocaine relapse.References
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